Neuroscience 2

4000 B.C. to 0 A.D ca. 4000 B.C. - Euphoriant effect of poppy plant reported in Sumerian records ca. 2700 B.C. - Shen Nung originates acupuncture ca. 1700 B.C. - Edwin Smith surgical papyrus written. First written record about the nervous system ca. 500 B.C. - Alcmaion of Crotona dissects sensory nerves 460-379 B.C. - Hippocrates discusses epilepsy as a disturbance of the brain 460-379 B.C. - Hippocrates states that the brain is involved with sensation and is the seat of intelligence 387 B.C. - Plato teaches at Athens. Believes brain is seat of mental process 335 B.C. - Aristotle writes on sleep; believes heart is seat of mental process 335-280 B.C. - Herophilus (the "Father of Anatomy"); believes ventricles are seat of human intelligence 280 B.C. - Erasistratus of Chios notes divisions of the brain 0 A.D. to 1500 177 - Galen lecture "On the Brain" ca. 100 - Marinus describes the tenth cranial nerve ca. 1000 - Alhazen compares the eye to a camera-like device 1316 - Mondino de'Luzzi writes the first European anatomy textbook (Anothomia) 1410 - Institution for the mentally ill established in Valencia, Spain 1500 - 1600 1504 - Leonardo da Vinci produces wax cast of human ventricles 1536 - Nicolo Massa describes the cerebrospinal fluid 1538 - Andreas Vesalius publishes Tabulae Anatomicae 1543 - Andreas Vesalius publishes "On the Workings of the Human Body" 1543 - Andreas Vesalius discusses pineal gland and draws the corpus striatum 1550 - Vesalius describes hydrocephalus 1550 - Bartolomeo Eustachio describes the brain origin of the optic nerves 1561 - Gabriele Falloppio publishes "Observationes Anatomicae" and describes some of the cranial nerves. Separate trochlear and abducens nerves identified 1562 - Bartolomeo Eustachio publishes "The Examination of the Organ of Hearing" 1564 - Aranzi coins the term "hippocampus" 1573 - Constanzo Varolio names the pons 1573 - Constanzo Varolio is first to cut brain starting at its base 1583 - Felix Platter states that the lens only focuses light 1586 - A. Piccolomini distinguishes between cortex and white matter 1587 - Giulio Cesare Aranzi describes ventricles and hippocampus 1590 - Zacharias Janssen invents the compound microscope 1596 - Sir Walter Raleigh mentions arrow poison in his book Discovery of the Large, Rich and Beautiful Empire of Guiana 1600 - 1700 1604 - Johannes Kepler describes inverted retinal image 1609 - J. Casserio publishes first description of mammillary bodies 1611 - Lazarus Riverius textbook describing impairments on consciousness published 1641 - Franciscus de la Boe Sylvius describes fissure on the lateral surface of the brain (Sylvian fissure) 1649 - Rene Descartes describes pineal as control center of body and mind 1650 - Franciscus de la Boe Sylvius describes a narrow passage between the third and fourth ventricles (the aqueduct of Sylvius) 1658 - Johann Jakof Wepfer theorizes that a broken brain blood vessel may cause apoplexy (stroke) 1661 - Thomas Willis describes a case of meningitis 1662 - Rene Descartes "De homine" is published (He died in 1650) 1664 - Thomas Willis publishes "Cerebri anatome" (in Latin) 1664 - Thomas Willis describes the eleventh cranial nerve 1664 - Gerardus Blasius discovers and names the "arachnoid." 1665 - Robert Hooke details his first microscope 1667 - Robert Hooke publishes "Micrographia" 1668 - l'Abbe Edme Mariotte discovers the blind spot 1670 - William Molins names the trochlear nerve 1673 - Joseph DuVerney uses experimental ablation technique in pigeons 1681 - English edition of Thomas Willis' "Cerebri anatome" was published 1681 - Thomas Willis coins the term Neurology 1684 - Raymond Vieussens publishes "Neurographia Universalis" 1684 - Raymond Vieussens uses boiling oil to harden the brain 1686 - Thomas Sydenham describes a form of chorea in children and young adults 1695 - Humphrey Ridley describes the restiform body 1695 - Humphrey Ridley publishes "The Anatomy of the Brain" 1697 - Joseph G. Duverney introduces the term "brachial plexus" 1700 - 1800 1704 - Antonio Valsalva publishes "On the Human Ear" 1705 - Antonio Pacchioni describes arachnoid granulations 1709 - Domenico Mistichelli describes pyramidal decussation 1717 - Antony van Leeuwenhoek describes nerve fiber in cross section 1721 - The word "anesthesia" first appears in English (in Dictionary Britannicum) 1736 - Jean Astruc coins the term reflex 1740 - Emanuel Swedenborg publishes "Oeconomia regni animalis" 1755 - J.B. Le Roy uses electroconvulsive therapy for mental illness 1760 - Arne-Charles Lorry demonstrates that damage to the cerebellum affects motor coordination 1764 - Domenico F.A. Cotugno describes spinal subarachnoid cerebrospinal fluid; shows that ventricular and spinal fluids are connected 1766 - Albrecht von Haller provides scientific description of the cerebrospinal fluid 1772 - John Walsh conducts experiments on torpedo (electric) fish 1773 - John Fothergill describes trigeminal neuralgia (tic douloureux, Fothergill's syndrome) 1773 - Sir Joseph Priestley discovers nitrous oxide 1774 - Franz Anton Mesmer introduces "animal magnetism" (later called hypnosis) 1776 - M.V.G. Malacarne publishes first book solely devoted to the cerebellum 1777 - Philip Meckel proposes that the inner ear is filled with fluid, not air 1778 - Samuel Thomas von Sommerring presents the modern classification of 12 cranial nerves 1779 - Antonius Scarpa describes Scarpa's ganglion of the vestibular system 1781 - Felice Fontana describes the microscopic features of axoplasm from an axon 1782 - Francesco Gennari publishes work on "lineola albidior" (later known as the stripe of Gennari) 1782 - Francesco Buzzi identifies the fovea 1783 - Alexander Monro describes the foramen of Monro 1786 - Felix Vicq d'Azyr discovers the locus coeruleus 1786 - Samuel Thomas Sommering describes the optic chiasm 1790 - Johannes Ehrenritter describes the glossopharygeal nerve ganglion 1791 - Luigi Galvani publishes work on electrical stimulation of frog nerves 1794 - John Dalton describes color blindness 1796 - Johann Christian Reil describes the insula (island of Reil) 1800 - 1850 1800 - Alessandro Volta invents the wet cell battery 1800 - Humphrey Davy synthesizes nitrous oxide 1800 - Samuel von Sommering identifies black material in the midbrain and calls it the "substantia nigra" 1801 - Thomas Young describes astigmatism 1801 - Adam Friedrich Wilhelm Serturner crystalizes opium and obtains morphine 1805 - Felix Vicq d'Azyr discovers the red nucleus 1808 - Franz Joseph Gall publishes work on phrenology 1809 - Johann Christian Reil uses alcohol to harden the brain 1809 - Luigi Rolando uses galvanic current to stimulate cortex 1811 - Julien Jean Legallois discovers respiratory center in medulla 1811 - Charles Bell discusses functional differences between dorsal and ventral roots of the spinal cord 1813 - Felix Vicq d'Azyr discovers the claustrum 1817 - James Parkinson publishes "An Essay on the Shaking Palsy" 1818 - Library of the Surgeon General's Office established (later to become the Army Medical Library and then the National Library of Medicine) 1820 - Galvanometer invented 1821 - Charles Bell describes facial paralysis ipsilateral to facial nerve lesion (Bell's palsy) 1821 - Francois Magendie discusses functional differences between dorsal and ventral roots of the spinal cord 1822 - Friedrich Burdach names the cingular gyrus 1822 - Friedrich Burdach distinguishes lateral and medial geniculate 1823 - Marie-Jean-Pierre Flourens states that cerebellum regulates motor activity 1824 - John C. Caldwell publishes "Elements of Phrenology" 1824 - Marie-Jean-Pierre Flourens details ablation to study behavior 1824 - F. Magendie provides first evidence of cerebellum role in equilibration 1825 - John P. Harrison first argues against phrenology 1825 - Jean-Baptiste Bouillaud presents cases of loss of speech after frontal lesions 1825 - Robert B. Todd discusses the role of the cerebral cortex in mentation, corpus striatum in movement and midbrain in emotion 1825 - Luigi Rolando describes the sulcus that separates the precentral and postcentral gyri 1826 - Johannes Muller publishes theory of "specific nerve energies" 1827 - F. Magendie discovers foramen of Magendie 1832 - Justus von Liebig discovers chloral hydrate 1832 - Jean-Pierre Robiquet isolates codeine 1833 - Philipp L. Geiger isolates atropine 1836 - Marc Dax reads paper on left hemisphere damage effects on speech 1836 - Gabriel Gustav Valentin identifies neuron nucleus and nucleolus 1836 - Robert Remak describes myelinated and unmyelinated axons 1836 - Charles Dickens (the novelist) describes obstructive sleep apnea 1837 - Jan Purkyne (Purkinje) describes cerebellar cells; identifies neuron nucleus and processes 1837 - The American Physiological Society is founded 1838 - Robert Remak suggests that nerve fiber and nerve cell are joined 1838 - Theordor Schwann describes the myelin-forming cell in the peripheral nervous system ("Schwann Cell") 1839 - Theordor Schwann proposes the cell theory 1839 - C. Chevalier coins the term microtome 1839 - Francois Leuret names the Rolandic sulcus for Luigi Rolando 1840 - Adolph Hannover uses chromic acid to harden nervous tissue 1840 - Jules Gabriel Francois Baillarger discusses the connections between white and gray matter of cerebral cortex 1842 - Benedikt Stilling is first to study spinal cord in serial sections 1842 - Crawford W. Long uses ether on man 1842 - Francois Magendie describes the median opening in the roof of the fourth ventricle (foramen of Magendie) 1843 - James Braid coins the term "hypnosis" 1844 - Robert Remak provides first illustration of 6-layered cortex 1844 - Horace Wells uses nitrous oxide during a tooth extraction 1846 - William Morton demonstrates ether anesthesia at Massachusetts General Hospital 1847 - Chloroform anesthesia used by James Young Simpson 1847 - American Medical Association is founded 1847 - The American Association for the Advancement of Science is founded 1848 - Phineas Gage has his brain pierced by an iron rod 1848 - Richard Owen coins the word "notochord" 1849 - Hermann von Helmholtz measures the speed of frog nerve impulses 1850 - 1900 1850 - Augustus Waller describes appearance of degenerating nerve fibers 1850 - Marshall Hall coins the term spinal shock 1850 - Emil Du Bois-Reymond invents nerve galvanometer 1851 - Heinrich Muller is first to describe the colored pigments in the retina 1851 - Marchese Alfonso Corti describes the cochlear receptor organ in the inner ear (organ of Corti) 1851 - Hermann von Helmholtz invents ophthalmoscope 1852 - A. Kolliker describes how motor nerves originate from the neurons in the anterior horn of the spinal cord 1852 - George Meissner and Rudolf Wagner describe encapsulated nerve endings later known as "Meissner's corpuscles" 1853 - William Benjamin Carpenter proposes "sensory ganglion" (thalamus) as seat of consciousness 1854 - Louis P. Gratiolet describes convolutions of the cerebral cortex 1855 - Bartolomeo Panizza shows the occipital lobe is essential for vision 1855 - Richard Heschl describes the transverse gyri in the temporal lobe (Heschl's gyri) 1859 - Charles Darwin publishes The Origin of Species 1859 - Rudolph Virchow coins the term "neuroglia" 1860 - Albert Niemann purifies cocaine 1860 - Gustav Theodor Fechner develops "Fechner's law" 1860 - Karl L. Kahlbaum describes and names "catatonia" 1861 - Paul Broca discusses cortical localization 1861 - T.H. Huxley coins the term "calcarine sulcus" 1862 - William Withey Gull describes clinical signs of syringomyelia 1862 - Hermann Snellen invents the eyechart with letters to test vision 1863 - Ivan Mikhalovich Sechenov publishes Reflexes of the Brain 1863 - Nikolaus Friedreich describes a progressive hereditary degenerative CNS disorder (Friedreich's ataxia) 1864 - John Hughlings Jackson writes on loss of speech after brain injury 1865 - Otto Friedrich Karl Deiters differentiates dendrites and axons 1865 - Otto Friedrich Karl Deiters describes the lateral vestibular nucleus (Deiter's nucleus) 1866 - John Langdon Haydon Down publishes work on congenital "idiots" 1866 - Julius Bernstein hypothesized that a nerve impulse is a "wave of negativity" 1867 - Theodore Meynert performs histologic analysis of cerebral cortex 1868 - Julius Bernstein measures the time course of the action potential 1868 - Friedrich Goll describes the fasciculus gracilis 1869 - Francis Galton claims that intelligence is inheredited (publication of Hereditary Genius) 1869 - Johann Friedrich Horner describes eye disorder (small pupil, droopy eyelid) later to be called "Horner's syndrome" 1870 - Eduard Hitzig and Gustav Fritsch discover cortical motor area of dog using electrical stimulation 1870 - Ernst von Bergmann writes first textbook on nervous system surgery 1871 - Weir Mitchell provides detailed account of phantom limb syndrome 1872 - George Huntington describes symptoms of a hereditary chorea 1872 - Sir William Turner describes the interparietal sulcus 1873 - Camillo Golgi publishes first work on the silver nitrate method 1874 - Vladimir Alekseyevich Betz publishes work on giant pyramidal cells 1874 - Roberts Bartholow electrically stimulates human cortical tissue 1874 - Carl Wernicke publishes "Der Aphasische Symptomencomplex" on aphasias 1875 - Sir David Ferrier describes different parts of monkey motor cortex 1875 - Richard Caton is first to record electrical activity from the brain 1875 - Wilhelm Heinrich Erb and Carl Friedrich Otto Westphal describe the knee jerk reflex 1876 - David Ferrier publishes "The Functions of the Brain" 1876 - Franz Christian Boll discovers rhodopsin 1876 - Francis Galton uses the term "nature and nurture" to explain "heredity and environment" 1877 - Jean-Martin Charcot publishes "Lectures on the Diseases of the Nervous System" 1878 - W. Bevan Lewis publishes work on giant pyramidal cells of human precentral gyrus 1878 - Claude Bernard describes nerve/muscle blocking action of curare 1878 - The first Ph.D. with "psychology" in its title is given to Granville Stanley Hall at Harvard University 1878 - Paul Broca publishes work on the "great limbic lobe" 1878 - W.R. Gowers publishes "Unilateral Gunshot Injury to the Spinal Cord" 1878 - Harmon Northrop Morse synthesized acetaminophen (paracetamol) 1878 - Louis-Antoine Ranvier describes regular interruptions in the myelin sheath (nodes of Ranvier) 1879 - Camillo Golgi describes the "musculo-tendineous organs" (later to be know as the "Golgi tendon organs") 1879 - William Crookes invents the cathode ray tube 1879 - Wilhelm Wundt sets up lab devoted to study human behavior 1880 - Jean Baptiste Edouard Gelineau introduces the word "narcolepsy" 1880 - Friedrich Sigmund Merkel describes free nerve endings later known as "Merkel's corpuscles" 1881 - Hermann Munk reports on visual abnormalities after occipital lobe ablation in dogs 1883 - Sir Victor Horsley describes effects of nitrous oxide anesthesia 1883 - Emil Kraepelin coins the terms neuroses and psychoses 1884 - Franz Nissl describes the granular endoplasmic reticulum ("Nissl Substance") 1884 - Karl Koller discovers anesthetic properties of cocaine 1884 - Georges Gilles de la Tourette describes several movement disorders 1885 - Paul Ehrlich notes that intravenous dye does not stain brain tissue 1885 - Carl Weigert introduces hematoxylin to stain myelin 1885 - Ludwig Edinger describes nucleus that will be known as the Edinger-Westphal nucleus 1886 - Joseph Jastrow earns the first Ph.D. from the first formal PhD program in psychology at Johns Hopkins University. 1886 - V. Marchi publishes procedure to stain degenerating myelin 1887 - Sergei Korsakoff describes symptoms characteristic in alcoholics 1887 - The National Institutes of Health established 1887 - Alfred Binet and C. Fere publish Animal Magnetism, a study on hypnosis 1887 - Adolf Eugen Fick makes the first contact lens out of glass for vision correction 1888 - William W. Keen, Jr. is first American to remove intracranial meningioma 1888 - Hans Chiari introduces the term "syringomyelia" 1888 - Giovanni Martinotti describes cortical cells later known as "Martinotti cells" 1889 - Santiago Ramon y Cajal argues that nerve cells are independent elements 1889 - William His coins the term dendrite 1889 - Sir Victor Horsley publishes somatotopic map of monkey motor cortex 1889 - Carlo Martinotti describes cortical neuron with ascending axon (this neuron now bears his name, Martinotti cell) 1889 - F.C. Muller-Lyer discovers the Muller-Lyer illusion 1890 - Wilhelm Ostwald discovers the membrane theory of nerve conduction 1890 - William James publishes Principles of Psychology 1891 - H. Quincke introduces the lumbar puncture 1891 - Wilhelm von Waldeyer coins the term neuron 1891 - Luigi Luciani publishes manuscript on the cerebellum 1891 - Heinrich Quinke develops the lumbar puncture (spinal tap) 1892 - Salomen Eberhard Henschen localizes vision to calcarine fissure 1892 - American Psychological Association formed 1893 - Paul Emil Flechsig describes myelinization of the brain 1893 - Charles Scott Sherrington coins the term proprioceptive 1894 - Franz Nissl stains neurons with dahlia violet 1895 - William His first uses the term hypothalamus 1895 - Wilhelm Konrad Roentgen invents the X-ray 1895 - Heinrick Quincke performs lumbar puncture to study cerebrospinal fluid 1895 - Formalization of the cranial nerve number system published in Basle Nomina Anatomica 1896 - Max von Frey details "stimulus hairs" to test the somatosensory system 1896 - Rudolph Albert von Kolliker coins the term axon 1896 - Camillo Golgi discovers the Golgi apparatus 1896 - Joseph Babinski describes the Babinski Sign 1896 - Emil Kraeplein describes dementia praecox 1897 - Ivan Petrovich Pavlov publishes work on physiology of digestion 1897 - Karl Ferdinand Braun invents the oscilloscope 1897 - John Jacob Abel isolates adrenalin 1897 - Charles Scott Sherrington coins the term synapse 1897 - Ferdinand Blum uses formaldehyde as brain fixative 1897 - Acetylsalicylic acid (aspirin) is synthesized by Felix Hoffmann 1898 - Charles Scott Sherrington describes decerebrate rigidity in cat 1898 - Edward Lee Thorndike describes the puzzle box 1898 - Bayer Drug Company markets heroin as nonaddicting cough medicine 1898 - John Newport Langley coins the term autonomic nervous system 1898 - Angelo Ruffini describes encapsulated nerve endings later known as Ruffini corpuscles 1899 - Francis Gotch describes a "refractory phase" between nerve impulses 1899 - Bayer AG introduces aspirin 1899 - August Bier uses cocaine for intraspinal anesthesia 1900 - 1950 1900 - Sigmund Freud publishes The Interpretation of Dreams 1900 - Charles Scott Sherrington states that cerebellum is head ganglion of the proprioceptive system 1900 - M. Lewandowsky coins the term "blood-brain barrier" (Bluthirnschranke) [ref: Aschner and Kerper, Mol. Biol. and Tox. of Metals, 2000] 1902 - Julius Bernstein proposes membrane theory for cells 1902 - Physiologist Ida Hyde is the first woman elected to the American Physiological Society 1903 - Ivan Pavlov coins the term conditioned reflex 1903 - Alfred Walter Campbell studies cytoarchitecture of anthropoid cerebral cortex 1904 - Procaine is synthesized 1905 - Alfred Binet and Theodore Simon have their first intelligence test 1905 - John Newport Langley coins the phrase "parasympathetic nervous system" 1906 - Alois Alzheimer describes presenile degeneration 1906 - Golgi and Cajal-Nobel Prize-Structure of the Nervous System 1906 - Sir Charles Scott Sherrington publishes The Integrative Action of the Nervous system that describes the synapse and motor cortex 1907 - Ross Granville Harrison describes tissue culture methods 1907 - John Newport Langley introduces the concept of receptor molecules 1908 - Vladimir Bekhterew describes the superior nucleus of the vestibular nerve (Bekhterew's nucleus) 1908 - Victor Alexander Haden Horsley and Robert Henry Clarke design stereotaxic instrument 1908 - Willem Einthoven makes string galvanometer recordings from the vagus nerve 1909 - Harvey Cushing is first to electrically stimulate human sensory cortex 1909 - Korbinian Brodmann describes 52 discrete cortical areas 1910 - Emil Kraepelin names Alzheimer's disease 1911 - Allvar Gullstrand-Nobel Prize-Optics of the eye 1911 - Eugen Bleuler coins the term schizophrenia 1911 - George Barger and Henry Dale discover norepinephrine (noradrenaline) 1913 - Santiago Ramon y Cajal develops gold chloride-mercury stain to show astrocytes 1913 - Edwin Ellen Goldmann finds blood brain barrier impermeable to large molecules 1913 - Edgar Douglas Adrian publishes work on all-or-none principle in nerve 1913 - Walter Samuel Hunter devises delayed-response test 1914 - Robert Barany-Nobel Prize-Vestibular apparatus 1914 - Henry H. Dale isolates acetylcholine 1915 - J.G. Dusser De Barenne describes activity of brain after strychnine application 1915 - Aspirin becomes available without a prescription 1916 - Richard Henneberg coins the term cataplexy 1916 - George Guillain, Jean Alexander Barre and Andre Strohl describe an acute inflammatory demyelinating polyneuropathy (Guillain-Barre Syndrome) 1918 - Walter E. Dandy introduces the ventriculography 1919 - Cecile Vogt describes over 200 cortical areas 1919 - Walter E. Dandy introduces the air encephalography 1919 - Gordon Morgan Holmes localizes vision to striate area 1919 - Pio del Rio Hortega divides neuroglia into microglia and oligodendroglia 1920 - Society of Neurological Surgeons is founded 1920 - Henry Head publishes "Studies in Neurology" 1920 - Stephen Walter Ranson demonstrates connections between the hypothalamus and pituitary 1921 - Otto Loewi publishes work on Vagusstoff 1921 - Hermann Rorschach develops the inkblot test 1921 - John Augustus Larsen and Leonard Keeler develop the polygraph 1921 - del Rio Hortega describes microglia 1922 - Army Medical Library established (was the Library of the Surgeon General's Office) 1924 - Charles Scott Sherrington discovers the stretch reflex 1925 - C. von Economo and G.N. Koskinas revise Brodmann's cortical nomenclature of the cerebral cortex 1926 - Percival Bailey and Harvey Cushing publish paper describing more the 2,000 neuroepithelial neoplasms 1927 - Chester William Darrow studies galvanic skin reflex in US 1928 - Philip Bard suggests the neural mechanism of rage is in the diencephalon 1928 - Walter Rudolph Hess reports "affective responses" to hypothalamic stimulation 1928 - John Fulton publishes his observations (made in 1926 and 1928) of the sounds of blood flowing over the human visual cortex 1929 - Hans Berger publishes his findings about the first human electroencephalogram 1929 - Karl Lashley defines "equipotentiality" and "mass action" 1927 - J. Wagner-Jauregg - Nobel Prize-Malaria to treat dementia paralyses 1929 - Joseph Erlanger and Herbert Spencer Gasser publish work on the correlation of nerve fiber size and function 1930 - John Carew Eccles shows central inhibition of flexor reflexes 1931 - Ulf Svante von Euler and J.H. Gaddum discover substance P 1932 - Max Knoll and Ernst Ruska invent the electron microscope 1932 - Jan Friedrich Tonnies develops multichannel ink-writing EEG machine 1932 - Edgar Douglas Adrian and Charles S. Sherrington share Nobel Prize for work on the function of neurons 1932 - Jan Friedrich Toennies and Brian Matthews design the differential amplifier 1932 - Walter B. Cannon coins the term homeostasis 1932 - Smith, Kline and French introduce the first amphetamine, Benzedrine 1933 - Ralph Waldo Gerard describes first experimental evoked potentials 1934 - S. Howard Bartley performs studies on cortical visual evoked potentials in rabbits 1935 - Frederic Bremer uses cerveau isole preparation to study sleep 1936 - Egas Moniz publishes work on the first human frontal lobotomy 1936 - Henry Hallett Dale and Otto Loewi share Nobel Prize for work on the chemical transmission between nerves 1936 - Walter Freeman performs first lobotomy in the United States 1937 - James Papez publishes work on limbic circuit 1936 - Massachusetts General Hospital has first EEG laboratory 1937 - Heinrich Kluver and Paul Bucy publish work on bilateral temporal lobectomies 1937 - James W. Papez develops "visceral theory" of emotion 1937 - John Zachary Young suggests that the squid giant axon can be used to understand nerve cells 1938 - B.F. Skinner publishes "The Behavior of Organisms" that describes operant conditioning 1938 - Albert Hofmann synthesizes LSD 1938 - Ugo Cerletti and Lucino Bini treat human patients with electroshock 1939 - Carl Pfaffman describes directionally sensitive cat mechanoreceptors 1939 - Nathaniel Kleitman publishes Sleep and Wakefulness 1942 - Stephen Kuffler develops the single nerve-muscle fiber preparation 1943 - John Raymond Brobeck describes hypothalamic hyperphasia 1944 - Joseph Erlanger and Herbert Spencer Gasser share Nobel Prize for work on the functions of single nerve fiber 1946 - Theodor Rasmussen describes the olivocochlear bundle (bundle of Rasmussen) 1946 - President Truman signed the National Mental Health Act 1947 - The American EEG Society is founded 1948 - The World Health Organization is founded 1949 - Kenneth Cole develops the voltage clamp 1949 - A.C.A.F. Egas Moniz-Nobel Prize-Leucotomy to treat certain psychoses 1949 - Walter Rudolph Hess receives Nobel Prize for work on the "Interbrain" 1949 - Horace Winchell Magoun defines the reticular activating system 1949 - John Cade discovers that lithium is an effective treatment for bipolar depression 1949 - Giuseppi Moruzzi and Horace Winchell Magoun publish Brain Stem Reticular Formation and Activation of the EEG 1949 - National Institute of Mental Health was formally established 1949 - Donald Olding Hebb publishes The Organization of Behavior: A Neuropsychological Theory 1950 - present 1950 - Karl Lashley publishes "In Search of the Engram" 1950 - Eugene Roberts and J. Awapara independently identify GABA in the brain 1950 - The National Institute of Neurological Disorders and Stroke established (it has gone through several name changes) 1951 - MAO-inhibitors introduced to treat psychotics 1952 - Alan Lloyd Hodgkin and Andrew Fielding Huxley first describe the voltage clamp 1953 - Eugene Aserinski and Nathaniel Kleitman describe rapid eye movements (REM) during sleep 1953 - H. Kluver and E. Barrera introduce Luxol fast blue MBS stain 1953 - Stephen Kuffler publishes work on center-surround, on-off organization of retinal ganglion cell receptive fields 1954 - James Olds describes rewarding effects of hypothalamic stimulation 1954 - John Lilly invents the "isolation tank" 1954 - Chlorpromazine was approved by the U.S. Food and Drug Administration 1956 - L. Leksell uses ultrasound to examine the brain 1956 - National Library of Medicine named (was the Army Medical Library) 1956 - Rita Levi-Montalcini and Stanley Cohen isolate and purify nerve growth factor 1957 - W. Penfield and T. Rasmussen devise motor and sensory humunculus 1957 - The American Medical Association recognizes alcoholism as a disease 1958 - Haloperidol introduced as a neuroleptic drug 1959 - P. Karlson and M. Lusher coin the term "pheromone" 1960 - Oleh Hornykiewicz shows that brain dopamine is lower than normal in Parkinson's disease patients 1961 - Georg Von Bekesy awarded the Nobel Prize for his work on the function of the cochlea 1961 - Levadopa successfully treats parkinsonism 1962 - Eldon Foltz performs the first cingulotomy to treat chronic pain 1963 - John Carew Eccles, Alan Lloyd Hodgkin and Andrew Fielding Huxley share Nobel Prize for work on the mechanisms of the neuron cell membrane 1965 - Ronald Melzack and Patrick D. Wall publish gate control theory of pain 1967 - Ragnar Arthur Granit, Halden Keffer Hartline and George Wald share Nobel Prize for work on the mechanisms of vision 1968 - National Eye Institute is established 1969 - D.V. Reynolds describes the analgesic effect of electrical stimulation of the periaqueductal gray 1969 - The Society for Neuroscience is founded 1970 - Julius Axelrod, Bernard Katz and Ulf Svante von Euler share Nobel Prize for work on neurotransmitters 1972 - Godfrey N. Hounsfield develops x-ray computed tomography 1973 - Candace Pert and Solomon Snyder demonstrate opioid receptors in brain 1973 - Sinemet is introduced as a treatment for Parkinson's disease 1973 - Konrad Z. Lorenz, Nikolaas Tinbergen and Karl von Frisch share Nobel Prize for work on ethology 1973 - Timothy Bliss and Terje Lomo describe long-term potentiation 1974 - National Institute on Drug Abuse established 1974 - International Association for the Study of Pain founded 1974 - John Hughes and Hans Kosterlitz discover enkephalin 1974 - M.E.Phelps, E.J.Hoffman and M.M.Ter Pogossian develop first PET scanner 1975 - John Hughes and Hans Kosterlitz publish work on enkephalins 1976 - Choh Hao Li and David Chung publish work on beta-endorphin 1976 - Erwin Neher and Bert Sakmann develop the patch-clamp technique 1977 - Roger Guillemin and Andrew Victor Schally share Nobel Prize for work on peptides in the brain 1981 - David Hunter Hubel and Torsten N. Wiesel-Nobel Prize-visual system 1981 - Roger Wolcott Sperry awarded Nobel Prize-functions brain hemispheres 1982 - Bengt Ingemar Bergstrom, John Robert Vane and Sune K. Bergstrom awarded Nobel Prize for the discovery of prostaglandins 1986 - Stanley Cohen and Rita Levi-Montalcini awarded Nobel prize for their work on the control of nerve cell growth 1987 - Fluoxetine (Prozac) introduced as treatment for depression 1990 - U.S. President George Bush declares the decade starting in 1990 the "Decade of the Brain" 1991 - Erwin Neher and Bert Sakmann share the Nobel Prize for their work on the function of single ion channels 1992 - National Institute on Drug Abuse becomes part of the National Institutes of Health 1993 - The gene responsible for Huntington's disease is identified 1994 - Alfred G. Gilman and Martin Rodbell share the Nobel Prize for their discovery of G-protein coupled receptors and their role in signal transduction 1997 - Stanley B. Prusiner awarded the Nobel Prize for the discovery of prions; a new biological principle of infection 2000 - Arvid Carlsson, Paul Greengard and Eric Kandel share the Nobel Prize for their discoveries concerning signal transduction in the nervous system